After the Hungarian army was destroyed at Mohács in 1526 and the Turks took Buda in 1541, the frontier crept north and every castle in this region was rebuilt for firearms. Hrušov was given a stone gate portal that still carries sixteenth-century work, and a cannon bastion on its southern side. In 1616 the whole estate was sold to Ladislav Pethe, because the Topoľčianky line that had held it died out. The war came closest in 1663, when the Ottomans took Nové Zámky and their raiding parties pushed deep into the Nitra region — but Hrušov was never an Ottoman conquest, and its end came out of a different war.Po zničení uhorského vojska pri Moháči v roku 1526 a po tureckom obsadení Budína v roku 1541 sa hranica posunula na sever a hrady v tomto kraji prestavovali pre strelné zbrane. Hrušov dostal kamenný vstupný portál, na ktorom sa dodnes zachovala práca zo 16. storočia, a delovú baštu na južnej strane. V roku 1616 celé panstvo predali Ladislavovi Petheovi, lebo topoľčianska vetva, ktorá ho dovtedy držala, vymrela. Najbližšie sa vojna dostala k hradu v roku 1663, keď Osmani dobyli Nové Zámky a ich lúpežné oddiely prenikli hlboko do Nitrianskeho kraja — Hrušov však nikdy nebol tureckým výbojom a jeho koniec priniesla iná vojna.
